● Vancomycin Hydrochloride - Antibacterial activity : inhibit bacterial cell wall synthesis - Mainly used as a treatment for beta-lactam antibiotic resistance in staphylococci of infectious diseases and penicillin susceptible patients. - Considered as drug of last resort in infectious disease treatment.  ● Teicoplanin - Teicoplanin is an antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. - Teicoplanin is a mixture of several compounds, five major (teicoplanin A2-1 through A2-5) and four minor (teicoplanin RS-1 through RS-4). All teicoplanins share the same glycopeptide core, teicoplanin A3-1 - a fused ring structure to which two carbohydrates (mannose and N-acetylglucosamine) are attached. - It is a lipopeptide antibiotic and it is semisynthetic antibiotic with a similar spectrum of activity to vancomycin. Its mechanism of action is to inhibit bacterial cell wall synthesis. - Its strength is considered to be due to the length of the hydrocarbon chain.  |
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